Transporter proteins knowledge graph construction and its application in drug development

Transporters are the main determinant for pharmacokinetics characteristics of drugs, such as absorption, distribution, and excretion of drugs in humans. However, it is difficult to perform drug transporter validation and structure analysis of membrane transporter proteins by experimental methods. Ma...

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Bibliographic Details

Published in:	Computational and Structural Biotechnology Journal
Main Authors:	Xiao-Hui Chen, Yao Ruan, Yan-Guang Liu, Xin-Ya Duan, Feng Jiang, Hao Tang, Hong-Yu Zhang, Qing-Ye Zhang
Format:	Article
Language:	English
Published:	Elsevier 2023-01-01
Subjects:	Transporter knowledge graph KG embedding Predictive model Generative model
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037023001836