Small-molecule SUMO inhibition for biomarker-informed B-cell lymphoma therapy

Aberrant activity of the SUMOylation pathway has been associated with MYC overexpression and poor prognosis in aggressive B-cell lymphoma (BCL) and other malignancies. Recently developed small-molecule inhibitors of SUMOylation (SUMOi) target the heterodimeric E1 SUMO activation complex (SAE1/UBA2)...

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Bibliographic Details

Published in:	Haematologica
Main Authors:	Uta M. Demel, Matthias Wirth, Schayan Yousefian, Le Zhang, Konstandina Isaakidis, Judith Dönig, Marlitt Böger, Nikita Singh, Hazal Köse, Simon Haas, Stefan Müller, Markus Schick, Ulrich Keller
Format:	Article
Language:	English
Published:	Ferrata Storti Foundation 2022-09-01
Online Access:	https://haematologica.org/article/view/10800