Vincamine induces cytoprotective autophagy via regulation of ampk/mtor signaling pathway in gentamicin-induced hepatotoxicity and nephrotoxicity in rats

Abstract Gentamicin (GET), a widely utilized aminoglycoside antibiotic for severe bacterial infections, is associated with significant hepatorenal toxicity. These adverse effects are frequently exacerbated by GET-induced oxidative stress and inflammation. This study aimed to evaluate the potential p...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Alaa Abouelhamd, Nourhan Elpry Mahmoud Shehata, Sara Mohamed Naguib Abdel-Hafez, Dalia H. Abu-Baih
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-06-01
Subjects:	Vincamine Gentamicin Nephrotoxicity Hepatotoxicity Autophagy.
Online Access:	https://doi.org/10.1038/s41598-025-06355-5