A novel vitamin D gene therapy for acute myeloid leukemia

Current treatment approaches for older adult patients with acute myeloid leukemia (AML) are often toxic and lack efficacy. Active vitamin D3 (1,25(OH)2D3) has been shown to induce myeloid blast differentiation but at concentrations that have resulted in unacceptable, off-target hypercalcemia in clin...

Full description

Bibliographic Details

Published in:	Translational Oncology
Main Authors:	Yi Xu, Kimberly Payne, Linh Hoang Gia Pham, Park Eunwoo, Jeffrey Xiao, David Chi, Justin Lyu, Rosalia Campion, Samiksha Wasnik, Il Seok Jeong, Xiaolei Tang, David Jeston Baylink, Chien Shing Chen, Mark Reeves, Mojtaba Akhtari, Saied Mirshahidi, Guido Marcucci, Huynh Cao
Format:	Article
Language:	English
Published:	Elsevier 2020-12-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S1936523320303612