Blockade of IL-36 receptor signaling does not prevent from TNF-induced arthritis.

INTRODUCTION: Interleukin (IL)-36α is a newly described member of the IL-1 cytokine family with a known inflammatory and pathogenic function in psoriasis. Recently, we could demonstrate that the receptor (IL-36R), its ligand IL-36α and its antagonist IL-36Ra are expressed in synovial tissue of arthr...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Anja Derer, Bettina Groetsch, Ulrike Harre, Christina Böhm, Jennifer Towne, Georg Schett, Silke Frey, Axel J Hueber
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Online Access:	http://europepmc.org/articles/PMC4128584?pdf=render