Polysialic acid restrains inflammatory monocyte maturation

Sialic acids are widely distributed monosaccharides in the central nervous system (CNS), where they are predominantly found as terminal sialic acid residues, as well as in di-, oligo-, and polysialic forms on the glycocalyx, collectively contributing to the development, resilience, and long-term int...

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Bibliographic Details
Published in:Frontiers in Immunology
Main Authors: Ingredy Passos, Benjamin Peschke, Shrey Gandhi, Judith Derdelinckx, Louisa Müller-Miny, Harald Neumann, Jan D. Lünemann, Christian W. Keller
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-10-01
Subjects:
polysialic acid
Siglec receptors
myeloid cells
neuroinflammation
autoimmunity
multiple sclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1656087/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1656087/full

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