TCAF1 promotes TRPV2-mediated Ca2+ release in response to cytosolic DNA to protect stressed replication forks

Abstract The protection of the replication fork structure under stress conditions is essential for genome maintenance and cancer prevention. A key signaling pathway for fork protection involves TRPV2-mediated Ca2+ release from the ER, which is triggered after the generation of cytosolic DNA and the...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Lingzhen Kong, Chen Cheng, Abigael Cheruiyot, Jiayi Yuan, Yichan Yang, Sydney Hwang, Daniel Foust, Ning Tsao, Emily Wilkerson, Nima Mosammaparast, Michael B. Major, David W. Piston, Shan Li, Zhongsheng You
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-05-01
Online Access:	https://doi.org/10.1038/s41467-024-48988-6