Au@109Pd core–shell nanoparticle conjugated to trastuzumab for the therapy of HER2+ cancers: studies on the applicability of 109Pd/109mAg in vivo generator in combined β− auger electron therapy

Abstract Background In radionuclide therapy, to enhance therapeutic efficacy, an intriguing alternative is to ensure the simultaneous implementation of low- and high-LET radiation emitted from a one radionuclide. In the present study, we introduce the concept of utilizing 109Pd (T1/2 = 13.7 h) in th...

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Bibliographic Details

Published in:	EJNMMI Radiopharmacy and Chemistry
Main Authors:	Nasrin Abbasi Gharibkandi, Kamil Wawrowicz, Agnieszka Majkowska-Pilip, Kinga Żelechowska-Matysiak, Mateusz Wierzbicki, Aleksander Bilewicz
Format:	Article
Language:	English
Published:	SpringerOpen 2023-10-01
Subjects:	109Pd/109mAg in vivo generator Radioimmunotherapy Auger electron therapy Nanotechnology
Online Access:	https://doi.org/10.1186/s41181-023-00212-4