MMR deficiency is frequent in colorectal carcinomas with diffuse SLFN11 immunostaining: clinicopathologic and molecular study of 31 cases identified among 3,300 tumors

Abstract Schlafen 11 (SLFN11), a regulator of cell fate following DNA injury, sensitizes tumor cells to DNA‐damaging agents. Patients with SLFN11‐positive tumors may benefit from DNA‐damaging chemotherapies. SLFN11 has been studied in different types of cancer including colorectal carcinomas. Howeve...

詳細記述

書誌詳細

出版年:	The Journal of Pathology: Clinical Research
主要な著者:	Maciej Kaczorowski, Małgorzata Chłopek, Ondřej Daum, Kris Ylaya, Tomáš Vaněček, Magdalena Szczepaniak, Karol Krawczyk, Artur Kowalik, Michal Michal, Jerzy Lasota, Markku Miettinen
フォーマット:	論文
言語:	英語
出版事項:	Wiley 2025-03-01
主題:	SLFN11 colorectal cancer mismatch repair proteins Lynch syndrome mucinous carcinoma DNA damaging agents
オンライン･アクセス:	https://doi.org/10.1002/2056-4538.70025