Cellular interferon-gamma and interleukin-2 responses to SARS-CoV-2 structural proteins are broader and higher in those vaccinated after SARS-CoV-2 infection compared to vaccinees without prior SARS-CoV-2 infection.

Class I- and Class II-restricted epitopes have been identified across the SARS-CoV-2 structural proteome. Vaccine-induced and post-infection SARS-CoV-2 T-cell responses are associated with COVID-19 recovery and protection, but the precise role of T-cell responses remains unclear, and how post-infect...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Martha Sedegah, Chad Porter, Emilie Goguet, Harini Ganeshan, Maria Belmonte, Jun Huang, Arnel Belmonte, Sandra Inoue, Neda Acheampong, Allison M W Malloy, Monique Hollis-Perry, Belinda Jackson-Thompson, Kathy F Ramsey, Yolanda Alcorta, Santina E Maiolatesi, Gregory Wang, Anatolio E Reyes, Luca Illinik, Margaret Sanchez-Edwards, Timothy H Burgess, Christopher C Broder, Eric D Laing, Simon D Pollett, Eileen Villasante, Edward Mitre, Michael R Hollingdale
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2022-01-01
Online Access:	https://doi.org/10.1371/journal.pone.0276241