Irisin restrains neuroinflammation in mouse experimental autoimmune encephalomyelitis via regulating microglia activation

IntroductionMultiple sclerosis is a chronic autoimmune demyelinating disorder predominantly affecting the white matter of the central nervous system, with experimental autoimmune encephalomyelitis (EAE) serving as its classical animal model. Irisin, a glycosylated protein derived from the proteolyti...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Qiu-Xia Zhang, Lin-Jie Zhang, Ning Zhao, Li Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Subjects:	irisin microglia EAE mechanism therapy neuroinflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1561939/full