Efficacy of BRAF/MEK-inhibitor therapy for epithelioid glioblastoma with a novel BRAFV600 mutation

Abstract Epithelioid glioblastoma (eGB), a very aggressive and rare brain tumour, is associated with a dismal median overall survival. Effective therapies for patients with eGB, particularly with leptomeningeal dissemination, are still lacking. Here, we describe a case of a 25-year-old male diagnose...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	J. Steininger, C. Buszello, R. Oertel, M. Meinhardt, S. Schmid, K. Engellandt, S. Herold, S. Stasik, A. Ebrahimi, B. Renner, C. Thiede, I.Y. Eyüpoglu, G. Schackert, S. Beissert, F. Meier, J. Radke, D. Westphal, T. A. Juratli
Format:	Article
Language:	English
Published:	BMC 2024-08-01
Subjects:	Epithelioid glioblastoma BRAF mutation MAPK inhibitors Leptomeningeal disease
Online Access:	https://doi.org/10.1186/s40478-024-01834-8