Population pharmacokinetics modelling to predict DDI from zopiclone on clozapine in schizophrenia patients

IntroductionClozapine, as a core drug for the treatment of schizophrenia, is widely used in the drug treatment of schizophrenia patients. However, when multiple drugs are used in combination, it is not clear whether there are drug-drug interactions (DDI) of clozapine in patients with schizophrenia....

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Bibliographic Details

Published in:	Frontiers in Psychiatry
Main Authors:	Huan-Huan Han, Yue Zhang, Jie Wang, Xue Tian, Ye Li, Su-Mei He, Cun Zhang, Xiao Chen, Dong-Dong Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	population pharmacokinetics modelling drug-drug interactions individualized therapy clozapine schizophrenia
Online Access:	https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1664678/full