Development and evaluation of mPEG-PLLA polymeric micelles encapsulating enrofloxacin for enhanced solubility, bioavailability, and antibacterial performance

The aim of this study was to prepare polymeric micelles composed of enrofloxacin (ENR) and methoxy poly (ethylene glycol)-poly(lactide) (mPEG-PLLA) using a solvent evaporation method to overcome the solubility-limited oral bioavailability of ENR. The formulation was optimized using a Box–Behnken des...

Full description

Bibliographic Details

Published in:	Frontiers in Veterinary Science
Main Authors:	Yanling Sun, Yanan Mao, Xin He, Xinghua Zhao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	enrofloxacin MPEG-PLLA micelles oral bioavailability antibacterial activity
Online Access:	https://www.frontiersin.org/articles/10.3389/fvets.2025.1595137/full