Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics

Therapeutic monoclonal antibodies and Fc-fusion proteins are successfully used in treatment of various diseases mainly including cancer, immune disease, and viral infection, which belong to the Fc-based therapeutics. In recent years, engineered Fc-derived antibody domains have also shown potential f...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Chunpeng Yang, Xinyu Gao, Rui Gong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-01-01
Subjects:	monoclonal antibody Fc-fusion protein Fc-based therapeutics optimization physicochemical property stability
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01860/full