Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence

Double strand breaks (DSBs) are highly toxic to a cell, a property that is exploited in radiation therapy. A critical component for the damage induction is cellular oxygen, making hypoxic tumor areas refractory to the efficacy of radiation treatment. During a fractionated radiation regimen, these hy...

Full description

Bibliographic Details

Published in:	Cells
Main Authors:	Apostolos Menegakis, Rob Klompmaker, Claire Vennin, Aina Arbusà, Maartje Damen, Bram van den Broek, Daniel Zips, Jacco van Rheenen, Lenno Krenning, René H. Medema
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Subjects:	hypoxia G1-arrest quiescence radiation resistance HPV
Online Access:	https://www.mdpi.com/2073-4409/10/3/610