cfDNA hydroxymethylcytosine profiling for detection metastasis and recurrence of Esophageal Squamous Cell Carcinoma

Abstract Background A blood-based approach to monitor metastasis and recurrence of esophageal squamous cell carcinoma (ESCC) remains undeveloped. This study aimed to establish a dependable model utilizing cfDNA 5-hydroxymethylcytosines (5hmC) signatures to detect these conditions in ESCC. Methods Th...

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Bibliographic Details

Published in:	World Journal of Surgical Oncology
Main Authors:	Subinuer Kuerban, Hangyu Chen, Long Chen, Lei Zhang, Xuehui Li, Baixin Zhen, Hong Xiao, Yingzhu Chen, Haitao Zhou, Zhen Liang, Guobing Xu, Yicun Tao, Jian Lin, Xiaozheng Kang
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	5-hydroxymethylcytosine Esophageal squamous cell carcinoma Liquid biopsy Metastasis Recurrence
Online Access:	https://doi.org/10.1186/s12957-025-03747-9