Obox4 promotes zygotic genome activation upon loss of Dux

Once fertilized, mouse zygotes rapidly proceed to zygotic genome activation (ZGA), during which long terminal repeats (LTRs) of murine endogenous retroviruses with leucine tRNA primer (MERVL) are activated by a conserved homeodomain-containing transcription factor, DUX. However, Dux-knockout embryos...

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書誌詳細

出版年:	eLife
主要な著者:	Youjia Guo, Tomohiro Kitano, Kimiko Inoue, Kensaku Murano, Michiko Hirose, Ten D Li, Akihiko Sakashita, Hirotsugu Ishizu, Narumi Ogonuki, Shogo Matoba, Masayuki Sato, Atsuo Ogura, Haruhiko Siomi
フォーマット:	論文
言語:	英語
出版事項:	eLife Sciences Publications Ltd 2024-06-01
主題:	zygotic genome activation retrotransposon transcription factors preimplantation development homeobox
オンライン･アクセス:	https://elifesciences.org/articles/95856