Local inhibition of angiogenesis results in an atrophic non-union in a rat osteotomy model

Long bone and in particular tibia fractures frequently fail to heal. A disturbed revascularisation is supposed to be a major cause for impaired bone healing or the development of non-unions. We aim to establish an animal model, which reliably mimics the clinical situation. Human microvascular endoth...

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Bibliographic Details

Published in:	European Cells & Materials
Main Authors:	M Fassbender, C Strobel, JS Rauhe, C Bergmann, G Schmidmaier, B Wildemann
Format:	Article
Language:	English
Published:	Forum Multimedia Publishing LLC 2011-07-01
Subjects:	Bone healing angiogenesis inhibition atrophic non-union
Online Access:	http://www.ecmjournal.org/journal/papers/vol022/pdf/v022a01.pdf