Rapid Development of an Effective Newcastle Disease Virus Vaccine Candidate by Attenuation of a Genotype VII Velogenic Isolate Using a Simple Infectious Cloning System

Genotype-matched vaccines provide ideal protection against infection caused by new Newcastle disease virus (NDV) genotypes or variants even in the vaccinated chickens. In this study, we report a protocol for attenuation and rapid development of a velogenic NDV isolate as an effective vaccine candida...

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Bibliographic Details

Published in:	Frontiers in Veterinary Science
Main Authors:	Nannan Wang, Mei Huang, To Sing Fung, Qiong Luo, Jun Xian Ye, Qian Ru Du, Liang Hai Wen, Ding Xiang Liu, Rui Ai Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-09-01
Subjects:	newcastle disease reverse genetics attenuated strains immune protection vaccination
Online Access:	https://www.frontiersin.org/article/10.3389/fvets.2020.00648/full