Human Smc5/6 recognises transcription-generated positive DNA supercoils
Abstract Beyond its essential roles in ensuring faithful chromosome segregation and genomic stability, the human Smc5/6 complex acts as an antiviral factor. It binds to and impedes the transcription of extrachromosomal DNA templates; an ability which is lost upon integration of the DNA into the chro...
| Published in: | Nature Communications |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-09-01
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| Online Access: | https://doi.org/10.1038/s41467-024-50646-w |