Successful Targeting of Somatic VHL Alterations With Belzutifan in Two Cases

Clear cell renal cell carcinoma (RCC) is commonly associated with alterations in the VHL tumor suppressor gene, resulting in upregulation of hypoxia-inducible factor pathways. Immune checkpoint inhibitors and vascular endothelial growth factor inhibitors are the mainstays of systemic treatment for m...

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Bibliographic Details

Published in:	Journal of Immunotherapy and Precision Oncology
Main Authors:	Bicky Thapa, Aditya Shreenivas, Kathryn Bylow, Hui-Zi Chen, Ben George, Razelle Kurzrock
Format:	Article
Language:	English
Published:	Innovative Healthcare Institute 2024-11-01
Subjects:	renal cell carcinoma hif hif-2α belzutifan vhl alterations
Online Access:	https://jipo.org/doi/pdf/10.36401/JIPO-24-13