Differences in Antioxidant and Lipid Handling Protein Expression Influence How Cells Expressing Distinct Mutant TP53 Subtypes Maintain Iron Homeostasis

The tumor suppressor TP53 is the most commonly mutated gene in human cancers, and iron is necessary for cancer cell growth and proliferation, but there is a significant gap in knowledge for how the two cooperate to affect cellular physiology. Elucidating this role is complicated, however, because ea...

Full description

Bibliographic Details

Published in:	Cells
Main Authors:	Cameron J. Cardona, Evan R. Hermann, Kate N. Kouplen, Steven D. Hartson, McKale R. Montgomery
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Subjects:	mutant TP53 iron metabolism ferroptosis cancer proteomics
Online Access:	https://www.mdpi.com/2073-4409/11/13/2064