Design, Synthesis, and Biological Evaluation of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase for the Efficient Treatment of Cancer

Ataxia telangiectasia mutated and Rad3-related (ATR), a vital member of the phosphatidylinositol 3-kinase-related kinase (PIKK) family, plays a critical role in the DNA damage response (DDR). Tumor cells with a loss of DDR function or defects in the ataxia telangiectasia mutated (ATM) gene are gener...

詳細記述

書誌詳細

出版年:	Molecules
主要な著者:	Jialu Shao, Lei Huang, Wenwen Lai, Yi Zou, Qihua Zhu
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2023-06-01
主題:	ATR ATR inhibitors ATM DDR synthetic lethality cancer
オンライン･アクセス:	https://www.mdpi.com/1420-3049/28/11/4521