The Role of Apoptosis and Oxidative Stress in a Cell Spheroid Model of Calcific Aortic Valve Disease

Calcific aortic valve disease (CAVD) is the most common heart valve disease among aging populations. There are two reported pathways of CAVD: osteogenic and dystrophic, the latter being more prevalent. Current two-dimensional (2D) in vitro CAVD models have shed light on the disease but lack three-di...

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Bibliographic Details

Published in:	Cells
Main Authors:	Colin W. Coutts, Ashley M. Baldwin, Mahvash Jebeli, Grace E. Jolin, Rozanne W. Mungai, Kristen L. Billiar
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Subjects:	valvular interstitial cell calcific aortic heart valve disease apoptosis oxidative stress antioxidant
Online Access:	https://www.mdpi.com/2073-4409/13/1/45