Piezo1 protects against inflammatory bone loss via a unique Ca2+-independent mechanism in osteoclasts

IntroductionBone integrity relies on mechanical stimulation, and its absence, such as in disuse osteoporosis or periodontitis, enhances osteoclast-mediated resorption. Although Piezo1 is a well-characterized mechanosensitive ion channel in several cell types, its function in osteoclast lineage cells...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Satoru Shindo, Shin Nakamura, Avery Hawthorne, Alireza Heidari, Maria Rita Pastore, Motoki Okamoto, Maiko Suzuki, Manuel Salinas, Takumi Memida, Dmitriy Minond, Alexander Bontempo, Mark Cayabyab, Yingzi Yang, Janet L Crane, Maria Hernandez, Saynur Vardar, Patrick Hardigan, Xiaozhe Han, Steven Kaltman, Toshihisa Kawai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	Piezo1 periodontitis osteoclast mechanosensing PP2A Akt
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1661538/full