Malaria parasite heme biosynthesis promotes and griseofulvin protects against cerebral malaria in mice

Abstract Heme-biosynthetic pathway of malaria parasite is dispensable for asexual stages, but essential for mosquito and liver stages. Despite having backup mechanisms to acquire hemoglobin-heme, pathway intermediates and/or enzymes from the host, asexual parasites express heme pathway enzymes and s...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Manjunatha Chandana, Aditya Anand, Sourav Ghosh, Rahul Das, Subhashree Beura, Sarita Jena, Amol Ratnakar Suryawanshi, Govindarajan Padmanaban, Viswanathan Arun Nagaraj
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-07-01
Online Access:	https://doi.org/10.1038/s41467-022-31431-z