Antineoplastic Activity of Water-Soluble Form of Novel Kinase Inhibitor 1-(4-Chlorobenzyl)-3-chloro-4-(3-trifluoromethylphenylamino)-1<i>H</i>-pyrrole-2,5-dione immobilized on Polymeric Poly(PEGMA-<i>co</i>-DMM) Carrier

The maleimide derivative 1-(4-chlorobenzyl)-3-chloro-4-(3-trifluoromethylphenylamino)-1<i>H</i>-pyrrole-2,5-dione (MI-1) was synthesized as inhibitor of several protein kinases, however, its application is hindered by its poor water solubility. In this study, the mechanisms of the antine...

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Bibliographic Details

Published in:	Scientia Pharmaceutica
Main Authors:	Nataliya Finiuk, Olga Klyuchivska, Nataliya Mitina, Halyna Kuznietsova, Kateryna Volianiuk, Alexander Zaichenko, Volodymyr Rybalchenko, Rostyslav Stoika
Format:	Article
Language:	English
Published:	MDPI AG 2022-01-01
Subjects:	1<i>H</i>-pyrrole-2,5-diones polymeric carrier cytotoxicity tumor cells apoptosis DNA damage
Online Access:	https://www.mdpi.com/2218-0532/90/1/7