Optimal dosing regimen of CD73 blockade improves tumor response to radiotherapy through iCOS downregulation

Background Irradiation (IR) and immune checkpoint inhibitor (ICI) combination is a promising treatment modality. However, local and distance treatment failure and resistance can occur. To counteract this resistance, several studies propose CD73, an ectoenzyme, as a potential target to improve the an...

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Bibliographic Details

Published in:	Journal for ImmunoTherapy of Cancer
Main Authors:	Pierre-Antoine Laurent, Eric Deutsch, Michele Mondini, Marine Gerbé De Thoré, Winchygn Liu, Lydia Meziani, Céline Clémenson, Marie-Catherine Vozenin
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2023-06-01
Online Access:	https://jitc.bmj.com/content/11/6/e006846.full