Notch Signaling Modulates Macrophage Polarization and Phagocytosis Through Direct Suppression of Signal Regulatory Protein α Expression

The Notch pathway plays critical roles in the development and functional modulation of myeloid cells. Previous studies have demonstrated that Notch activation promotes M1 polarization and phagocytosis of macrophages; however, the downstream molecular mechanisms mediating Notch signal remain elusive....

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yan Lin, Jun-Long Zhao, Qi-Jun Zheng, Xun Jiang, Jiao Tian, Shi-Qian Liang, Hong-Wei Guo, Hong-Yan Qin, Ying-Min Liang, Hua Han
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-07-01
Subjects:	macrophages notch signal regulatory protein α SHP-1 polarization phagocytosis
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01744/full