Midodrine for Sepsis Treatment and Early Vasopressor Weaning (MID-STEP): protocol for a pragmatic randomised clinical trial

Introduction Sepsis is a global health priority with nearly 50 million cases annually. Cardiovascular dysfunction is common, frequently manifesting as hypotension that persists despite fluid resuscitation. Most affected patients require the use of intravenous (IV) vasoactive agents, typically necess...

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Bibliographic Details

Published in:	BMJ Open
Main Authors:	Amos Lal, Rodrigo Cartin-Ceba, Vikas Bansal, Devang Sanghavi, Ognjen Gajic, Aryan Shiari, Erin F Barreto, Aysun Tekin, Gabriele Halpern, Diksha Gowda, Amy Schuchard, Anes Joguncic, Phillip Schulte, Yewande E Odeyemi, Sumera Ahmad, Bo Madsen, Zeeshan Rizwan, Swetha Reddy, Vatsa Bhavsar, Juan Pablo Domecq Garces, Syed Anjum Khan
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2026-04-01
Online Access:	https://bmjopen.bmj.com/content/16/4/e117846.full