ProS1-MerTK signaling in CD4 T cells: implications for TIL expansion and functionality

Cancer immunotherapy predominantly targets CD8 T cells, but recent evidence highlights the importance of CD4 T cells in adoptive cell therapy (ACT). The TAM receptor MerTK regulates immune responses and has been shown to provide costimulatory signals in CD8 T cells. However, its role in CD4 T cells...

Full description

Bibliographic Details

Published in:	OncoImmunology
Main Authors:	Annina Kurzay, Sara Fresnillo Saló, Anne Rahbech, Tina Seremet, Cecilie Oelvang Madsen, Christopher Aled Chamberlain, Emilie Bülow Jensen, Viet Thy Luu, Özcan Met, Marlies J W Peeters, Per thor Straten
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	Adoptive cell therapy immunotherapy melanoma T cell TAM-receptor tumour infiltrating lymphocyte
Online Access:	https://www.tandfonline.com/doi/10.1080/2162402X.2025.2532662