A general approach for stabilizing nanobodies for intracellular expression

Conventional antibodies and their derived fragments are difficult to deploy against intracellular targets in live cells, due to their bulk and structural complexity. Nanobodies provide an alternative modality, with well-documented examples of intracellular expression. Despite their promise as intrac...

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Bibliographic Details
Published in:eLife
Main Authors: John G Dingus, Jonathan CY Tang, Ryoji Amamoto, Grace K Wallick, Constance L Cepko
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Subjects:
nanobody
intracellular expression
stability
intrabody
Online Access:https://elifesciences.org/articles/68253

Internet

https://elifesciences.org/articles/68253

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