Hybrid peptide NTP-217 triggers ROS-mediated rapid necrosis in liver cancer cells by induction of mitochondrial leakage

Liver cancer is the third leading cause of cancer-associated mortality globally, and >830,000 patients with liver cancer undergoing treatment succumbed to the disease in 2020, which indicates the urgent need to develop a more effective anti-liver cancer drug. In our previous study, nucleus-ta...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Hao Yin, Xingyan Fu, Hanyu Gao, Han Gao, Yannan Ma, Xitong Chen, Xueqi Zhang, Shan-Shan Du, Yun-Kun Qi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Subjects:	hybrid peptides liver cancer mitochondria ROS necrosis apoptosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.1028600/full