TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation

Abstract Background TREM2 is a transmembrane receptor expressed by myeloid cells and acts to regulate their immune response. TREM2 governs the response of microglia to amyloid and tau pathologies in the Alzheimer’s disease (AD) brain. TREM2 is also present in a soluble form (sTREM2), and its CSF lev...

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Bibliographic Details

Published in:	Genome Medicine
Main Authors:	Miguel Moutinho, Israel Coronel, Andy P. Tsai, Gonzalo Viana Di Prisco, Taylor Pennington, Brady K. Atwood, Shweta S. Puntambekar, Daniel C. Smith, Pablo Martinez, Seonggyun Han, Younghee Lee, Cristian A. Lasagna-Reeves, Bruce T. Lamb, Stephanie J. Bissel, Kwangsik Nho, Gary E. Landreth
Format:	Article
Language:	English
Published:	BMC 2023-02-01
Subjects:	TREM2 Soluble TREM2 TREM2 splicing Alzheimer’s disease
Online Access:	https://doi.org/10.1186/s13073-023-01160-z