Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia

Summary: The derivation of microglia from human stem cells provides systems for understanding microglial biology and enables functional studies of disease-causing mutations. We describe a robust method for the derivation of human microglia from stem cells, which are phenotypically and functionally c...

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Bibliographic Details

Published in:	Stem Cell Reports
Main Authors:	Philip W. Brownjohn, James Smith, Ravi Solanki, Ebba Lohmann, Henry Houlden, John Hardy, Sabine Dietmann, Frederick J. Livesey
Format:	Article
Language:	English
Published:	Elsevier 2018-04-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671118301097