Interaction of Tau with Kinesin-1: Effect of Kinesin-1 Heavy Chain Elimination on Autophagy-Mediated Mutant Tau Degradation

Natively unfolded tau has a low propensity to form aggregates, but in tauopathies, such as Alzheimer’s disease (AD), tau aggregates into paired helical filaments (PHFs) and neurofibrillary tangles (NFTs). Multiple intracellular transport pathways utilize kinesin-1, a plus-end-directed microtubule-ba...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Karthikeyan Selvarasu, Abhay Kumar Singh, Avinash Dakshinamoorthy, Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Moorthi Radhakrishnan, Supriti Patnaik, Jian-Dong Huang, Leonard L. Williams, Sanjib Senapati, Siva Sundara Kumar Durairajan
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Subjects:	Alzheimer’s disease tau kinesin 1 heavy chain KIF5B ATPase autophagy
Online Access:	https://www.mdpi.com/2227-9059/12/1/5