Synthesis and Docking Studies of 2,4,6-Trihydroxy-3-Geranylacetophenone Analogs as Potential Lipoxygenase Inhibitor

The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Molecules
المؤلفون الرئيسيون:	Chean Hui Ng, Kamal Rullah, Mohd Fadhlizil Fasihi Mohd Aluwi, Faridah Abas, Kok Wai Lam, Intan Safinar Ismail, Radhakrishnan Narayanaswamy, Fadzureena Jamaludin, Khozirah Shaari
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	MDPI AG 2014-08-01
الموضوعات:	lipoxygenase analogs Friedel-Craft acylation Friedel-Craft alkylation molecular docking
الوصول للمادة أونلاين:	http://www.mdpi.com/1420-3049/19/8/11645