GPER limits adverse changes to Ca2+ signalling and arrhythmogenic activity in ovariectomised guinea pig cardiomyocytes

Background: The increased risk of post-menopausal women developing abnormalities of heart function emphasises the requirement to understand the effect of declining oestrogen levels on cardiac electrophysiology and structure, and investigate possible therapeutic targets, namely the G protein-coupled...

Full description

Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Alice J. Francis, Jahn M. Firth, Jose L. Sanchez-Alonso, Julia Gorelik, Kenneth T. MacLeod
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	oestrogen anti-arrhythmia cardiac excitation contraction coupling cardiacelectrophysiology GPER activation GPER agonist G-1
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2022.1023755/full