Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature

Abstract Background Primary mesenchymal stem cells (MSCs) are fraught with aging-related shortfalls. Human-induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) have been shown to be a useful clinically relevant source of MSCs that circumvent these aging-associated drawbacks. To date, the extent...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Lucas-Sebastian Spitzhorn, Matthias Megges, Wasco Wruck, Md Shaifur Rahman, Jörg Otte, Özer Degistirici, Roland Meisel, Rüdiger Volker Sorg, Richard O. C. Oreffo, James Adjaye
Format:	Article
Language:	English
Published:	BMC 2019-03-01
Subjects:	Aged MSC Fetal MSCs iPSCs iMSCs Transcriptome Secretome
Online Access:	http://link.springer.com/article/10.1186/s13287-019-1209-x