Exploring Amantadine Derivatives as Urease Inhibitors: Molecular Docking and Structure–Activity Relationship (SAR) Studies

This article describes the design and synthesis of a series of novel amantadine-thiourea conjugates (<b>3a</b>–<b>j</b>) as Jack bean urease inhibitors. The synthesized hybrids were assayed for their in vitro urease inhibition. Accordingly, <i>N</i>-(adamantan-1-y...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Atteeque Ahmed, Aamer Saeed, Omar M. Ali, Zeinhom M. El-Bahy, Pervaiz Ali Channar, Asma Khurshid, Arfa Tehzeeb, Zaman Ashraf, Hussain Raza, Anwar Ul-Hamid, Mubashir Hassan
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Subjects:	acyl/aroyl thioureas urease inhibitors synthesis enzyme inhibitory kinetics molecular docking
Online Access:	https://www.mdpi.com/1420-3049/26/23/7150