Transcriptomic subtyping of malignant peripheral nerve sheath tumours highlights immune signatures, genomic profiles, patient survival and therapeutic targetsResearch in context

Summary: Background: Malignant peripheral nerve sheath tumour (MPNST) is an aggressive orphan disease commonly affecting adolescents or young adults. Current knowledge of molecular tumour biology has been insufficient for development of rational treatment strategies. We aimed to discover molecular...

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Bibliographic Details

Published in:	EBioMedicine
Main Authors:	Maren Høland, Kaja C.G. Berg, Ina A. Eilertsen, Bodil Bjerkehagen, Matthias Kolberg, Kjetil Boye, Ole Christian Lingjærde, Tormod K. Guren, Nils Mandahl, Eva van den Berg, Emanuela Palmerini, Sigbjørn Smeland, Piero Picci, Fredrik Mertens, Anita Sveen, Ragnhild A. Lothe
Format:	Article
Language:	English
Published:	Elsevier 2023-11-01
Subjects:	MPNST Transcriptomic subtypes DNA copy number aberrations Data integration Prognosis
Online Access:	http://www.sciencedirect.com/science/article/pii/S235239642300395X