XMU-MP-1 attenuates osteoarthritis via inhibiting cartilage degradation and chondrocyte apoptosis

Osteoarthritis (OA) is the most prevalent type of degenerative joint disease; it is reported to be associated with inflammatory responses, chondrocyte apoptosis, and cartilage degeneration. XMU-MP-1 is a selective MST1/2 inhibitor which activates the downstream effector YAP and promotes cell growth....

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Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Xue Hao, Jing Zhao, Liyuan Jia, Ting He, Huanbo Wang, Jing Fan, Yating Yang, Fei Su, Qingda Lu, Chao Zheng, Liu Yang, Qiang Jie
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	osteoarthritis XMU-MP-1 Hippo signaling chondrocyte cartilage
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2022.998077/full