Bone marrow mesenchymal stem cells expressing Neat-1, Hotair-1, miR-21, miR-644, and miR-144 subsided cyclophosphamide-induced ovarian insufficiency by remodeling the IGF-1–kisspeptin system, ovarian apoptosis, and angiogenesis

Abstract Ovarian insufficiency is one of the common reproductive disorders affecting women with limited therapeutic aids. Mesenchymal stem cells have been investigated in such disorders before yet, the exact mechanism of MSCs in ovarian regeneration regarding their epigenetic regulation remains elus...

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Bibliographic Details

Published in:	Journal of Ovarian Research
Main Authors:	Amany I. Ahmed, Mohamed F. Dowidar, Asmaa F. Negm, Hussein Abdellatif, Asma Alanazi, Mohammed Alassiri, Walaa Samy, Dina Mohamed Mekawy, Eman M. A. Abdelghany, Nesma I. El-Naseery, Mohamed A. Ibrahem, Emad Ali Albadawi, Wed Salah, Mamdouh Eldesoqui, Emil Tîrziu, Iulia Maria Bucur, Ahmed Hamed Arisha, Tarek Khamis
Format:	Article
Language:	English
Published:	BMC 2024-09-01
Subjects:	lncRNA microRNAs Premature ovarian failure Cyclophosphamide BM-MSCs HPG
Online Access:	https://doi.org/10.1186/s13048-024-01498-x