Spinal neuromodulation mitigates myocardial ischemia-induced sympathoexcitation by suppressing the intermediolateral nucleus hyperactivity and spinal neural synchrony

IntroductionMyocardial ischemia disrupts the cardio-spinal neural network that controls the cardiac sympathetic preganglionic neurons, leading to sympathoexcitation and ventricular tachyarrhythmias (VTs). Spinal cord stimulation (SCS) is capable of suppressing the sympathoexcitation caused by myocar...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Siamak Salavatian, Yuki Kuwabara, Benjamin Wong, Jonathan R. Fritz, Kimberly Howard-Quijano, Robert D. Foreman, J. Andrew Armour, Jeffrey L. Ardell, Aman Mahajan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Subjects:	spinal cord stimulation neuromodulation myocardial ischemia autonomic nervous system arrhythmias spinal neural network
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2023.1180294/full