Inhibition of DNA Topoisomerase Ι by Flavonoids and Polyacetylenes Isolated from <i>Bidens pilosa</i> L.

Human DNA topoisomerase I (Topo I) is an essential enzyme in regulating DNA supercoiling during transcription and replication, and it is an important therapeutic target for anti-tumor agents. <i>Bidens pilosa</i> L. is a medicinal herb that is used as a folk medicine for cancers in China...

Full description

Bibliographic Details

Published in:	Molecules
Main Authors:	Guiyuan Zeng, Yinyue Wang, Meihua Zhu, Jumei Yi, Junjie Ma, Bijuan Yang, Weiqing Sun, Fang Dai, Junlin Yin, Guangzhi Zeng
Format:	Article
Language:	English
Published:	MDPI AG 2024-07-01
Subjects:	<i>Bidens pilosa</i> L. flavonoids polyacetylenes cytotoxicity DNA topoisomerase I structure–activity analysis
Online Access:	https://www.mdpi.com/1420-3049/29/15/3547