Impact of Confounding Factors in Human Postmortem Brain Tissues on Gene Expression Profiles: A Comparison of Patients With Schizophrenia, Bipolar Disorder, and Nonpsychiatric Controls

ABSTRACT Controlling for confounding factors in postmortem brain studies of psychiatric disorders is crucial, particularly in gene expression analyses. Potential confounding factors include sex, age at death, medication history, agonal state, postmortem interval (PMI), tissue storage duration, tissu...

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Bibliographic Details

Published in:	Neuropsychopharmacology Reports
Main Authors:	Masataka Hatano, Atsuko Nagaoka, Kazusa Miyahara, Yuto Hosogai, Risa Shishido, Hideomi Hamasaki, Mizuki Hino, Akiyoshi Kakita, Hiroaki Tomita, Yasuto Kunii, Itaru Miura
Format:	Article
Language:	English
Published:	Wiley 2025-09-01
Subjects:	bipolar disorder confounding factor postmortem brain RNA‐seq schizophrenia
Online Access:	https://doi.org/10.1002/npr2.70053