Polyamine and EIF5A hypusination downstream of c-Myc confers targeted therapy resistance in BRAF mutant melanoma

Abstract Background BRAF inhibitors are widely employed in the treatment of melanoma with the BRAF V600E mutation. However, the development of resistance compromises their therapeutic efficacy. Diverse genomic and transcriptomic alterations are found in BRAF inhibitor resistant melanoma, posing a pr...

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Bibliographic Details
Published in:Molecular Cancer
Main Authors: Byung-Sun Park, Heeju Jeon, Yeonseo Kim, Haejin Kwon, Ga-Eun Choi, Sung-Gil Chi, Hyun-Mee Park, Hyunbeom Lee, Tackhoon Kim
Format: Article
Language:English
Published: BMC 2024-07-01
Subjects:
Melanoma
BRAF
Vemurafenib
Polyamine
Hypusination
c-Myc
Online Access:https://doi.org/10.1186/s12943-024-02031-w

Internet

https://doi.org/10.1186/s12943-024-02031-w

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