Oxidative Stress-Related Mechanisms in Melanoma and in the Acquired Resistance to Targeted Therapies

Melanoma is a highly aggressive cancer with the poorest prognosis, representing the deadliest form of skin cancer. Activating mutations in BRAF are the most frequent genetic alterations, present in approximately 50% of all melanoma cases. The use of specific inhibitors towards mutant BRAF variants a...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Stefania Pizzimenti, Simone Ribero, Marie Angele Cucci, Margherita Grattarola, Chiara Monge, Chiara Dianzani, Giuseppina Barrera, Giuliana Muzio
Format:	Article
Language:	English
Published:	MDPI AG 2021-12-01
Subjects:	melanoma targeted therapies BRAFi MEKi resistance oxidative stress
Online Access:	https://www.mdpi.com/2076-3921/10/12/1942