Valproic acid exhibits anti-tumor activity selectively against EGFR/ErbB2/ErbB3-coexpressing pancreatic cancer via induction of ErbB family members-targeting microRNAs

Abstract Background Deregulated ErbB signaling plays an important role in tumorigenesis of pancreatic cancer. However, patients with pancreatic cancer benefit little from current existed therapies targeting the ErbB signaling. Here, we explore the potential anti-tumor activity of Valproic acid again...

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Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Tingting Lin, Qun Ren, Weimin Zuo, Ruxue Jia, Linhui Xie, Rong Lin, Hu Zhao, Jin Chen, Yan Lei, Ping Wang, Huiyue Dong, Lianghu Huang, Jinquan Cai, Yonghai Peng, Zongyang Yu, Jianming Tan, Shuiliang Wang
Format:	Article
Language:	English
Published:	BMC 2019-04-01
Subjects:	Valproic acid Pancreatic cancer ErbB family members microRNAs
Online Access:	http://link.springer.com/article/10.1186/s13046-019-1160-9